What type of drug is diphenhydramine?

Diphenhydramine is an antihistamine used to temporarily relieve symptoms due to hay fever, upper respiratory allergies, or the common cold, such as runny nose and sneezing. It works by blocking histamine in the body, which is a substance that causes allergic symptoms.

Is diphenhydramine a CYP3A4 inhibitor?

The risk is heightened because the levels of these drugs increase in the presence of inhibitors of cytochrome P450 3A4 (CYP3A4). Recently, diphenhydramine (DPH) (Benadryl and others), the prototypic H1-receptor antagonist, has been found to inhibit CYP2D6 in vitro.

Is Acrivastine the same as diphenhydramine?

Acrivastine is also called by the brand name Benadryl Allergy Relief. When it’s mixed with pseudoephedrine, it’s called Benadryl Allergy Relief Plus Decongestant.

Is it bad to take diphenhydramine every night?

The bottom line. Peoplpe sometimes use antihistamines, such as diphenhydramine and doxylamine succinate, to combat insomnia. These over-the-counter medications are OK for occasional use in most people. However, they may increase the risk for dementia and Alzheimer’s disease if taken long-term.

Is diphenhydramine bad for your liver?

Hepatotoxicity. Despite widespread use over many decades, diphenhydramine has not been linked to liver test abnormalities or to clinically apparent liver injury. The reason for its safety may relate its short half-life and limited duration of use.

What happens if I mix diphenhydramine?

Taking them together is dangerous because they can slow down your CNS too much. This can cause drowsiness, sedation, and trouble doing physical and mental tasks that require alertness. In short, Benadryl and alcohol shouldn’t be used together.

How does diphenhydramine work as an antihistamine?

Diphenhydramine is a first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine -1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles.

What is the pH of diphenhydramine hydrochloride solution?

Diphenhydramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material Diphenhydramine hydrochloride appears as white or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.

What’s the trade name for the drug diphenhydramine?

Diphenhydramine is marketed under the trade name Benadryl by McNeil Consumer Healthcare in the U.S., Canada, and South Africa. Trade names in other countries include Dimedrol, Daedalon, and Nytol.

Is there a link between diphenhydramine and liver injury?

Diphenhydramine has not been linked to instances of clinically apparent acute liver injury. Diphenhydramine is an ether that is the benzhydryl ether of 2- (dimethylamino)ethanol.