What is sequence in transcription?

A specific DNA sequence to which RNA polymerase binds and initiates transcription. This region contains information which regulates when and how often the gene is transcribed and ultimately the amount of protein it produces.

What is an example of a regulatory sequence?

These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. Among this constellation of sequences, enhancers and their associated transcription factor proteins have a leading role in the regulation of gene expression.

What is an enhancer sequence?

Enhancer sequences are regulatory DNA sequences that, when bound by specific proteins called transcription factors, enhance the transcription of an associated gene. Because DNA is folded and coiled in the nucleus, the enhancer may actually be located near the transcription start site in the folded state.

What is DNA regulatory elements?

A variety of DNA regulatory elements are involved in the regulation of gene expression and rely on the biochemical interactions involving DNA, the cellular proteins that make up chromatin, and transcription factors. Promoters and enhancers are the primary genomic regulatory components of gene expression.

Is the promoter a regulatory sequence?

The regulatory sequences include the promoter region together with enhancer elements. Every gene has a promoter, which is the binding site for the basal transcriptional apparatus – RNA polymerase and its co-factors.

Is the operator a regulatory sequence?

Most operons have other regulatory DNA sequences in addition to the promoter. These sequences are binding sites for regulatory proteins that turn expression of the operon “up” or “down.” Some regulatory proteins are repressors that bind to pieces of DNA called operators.

Can enhancers be in exons?

Enhancers are often found in noncoding sequences in close proximity to the gene that they regulate and sometimes even on another chromosome; however, whether they are also found in exons, the coding regions of DNA, is unclear. Thus, exonic sequences may function in the regulation of nearby genes.