What is MLL cancer?
What is MLL cancer?
The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases.
What does 11q23 mean?
Abstract. 11q23 translocations (t(11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL). Mixed lineage antigen expression has been reported in these leukemias, but its frequency and clinical significance are unknown.
What is 11q23 deletion?
Deletion of 11q23 is a highly specific nonrandom secondary genetic abnormality of ETV6/RUNX1-rearranged childhood acute lymphoblastic leukemia. Leukemia 21, 584–586 (2007).
What is MLL translocation?
Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA-binding protein that methylates histone H3 lysine 4 (H3K4), and positively regulates gene expression including multiple Hox genes.
Where is the MLL gene located on chromosome 11q23?
Purpose of review: Rearrangements of the histone lysine [K]-MethylTransferase 2A gene (KMT2A) gene on chromosome 11q23, formerly known as the mixed-lineage leukemia (MLL) gene, are found in 10% and 5% of adult and children ALL cases, respectively.
Are there any translocations of the MLL gene?
The MLL gene on 11q23 is involved in a number of translocations with different partner chromosomes. The most common translocations observed in childhood AML are the t(9;11)(p21;q23) and the t(11;19)(q23;p13.1); other translocations of 11q23 involve at least 30 different partners chromosomes.
What kind of leukemia has chromosome band 11q23?
Translocations involving the chromosome band 11q23 occur frequently in hematologic cancers, affecting 7 to 10 percent of acute lymphoblastic leukemias (ALLs), with the (4;11) and (11;19) translocations predominating, and 5 to 6 percent of AMLs, with the (6;11), (9;11), and (11;19) translocations being the most common 4-8.
What is the incidence of AML with 11q23 / MLL abnormalities?
In an unselected series of 1897 AML cases, 54 patients with an 11q23/ MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence of AML with MLL rearrangement was significantly higher in therapy-related AML (t-AML) than in de novo AML (9.4% vs 2.6%, P < .0001).