What does glial fibrillary acidic protein do?

If brain or spinal cord cells are injured through trauma or disease, astroglial cells react by rapidly producing more glial fibrillary acidic protein. Although its function is not fully understood, glial fibrillary acidic protein is probably involved in controlling the shape, movement, and function of astroglial cells.

What is the function of GFAP?

GFAP is an intermediate filament protein (Eng et al., 2000) expressed primarily by astrocytes in the CNS. Its main function is to maintain astrocyte structural integrity and aid in cell movement and shape change (Eng et al., 2000).

Is GFAP a membrane protein?

Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans….Glial fibrillary acidic protein.

GFAP
showGene ontology
Orthologs
Species	Human	Mouse
Entrez	2670	14580

What is GFAP astrocyte?

Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes have a range of control and homeostatic functions in health and disease.

Are glial cells proteins?

Glial fibrillary acidic protein (GFAP) is an intermediate filament-III protein uniquely found in astrocytes in the CNS, non-myelinating Schwann cells in the PNS and enteric glial cells. GFAP mRNA expressions are regulated by several nuclear-receptor hormones, growth factors and lipopolysaccharides.

What cells are GFAP positive?

GFAP (Glial Fibrillary Acidic Protein)-Positive Progenitor Cells Contribute to the Development of Vascular Smooth Muscle Cells and Endothelial Cells-Brief Report. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1231-1238.

Is GFAP a surface marker?

We have characterized five distinct cell surface antigens of human astrocytomas and correlated their expression with the expression of glial fibrillary acidic protein (GFAP) and four previously defined cell surface markers of astrocytomas.

Is GFAP a cytosolic protein?

Because GFAP is a cytosolic intermediate filament protein of astrocytes, methods for the detection of its antibody are limited.

What is the glial fibrillary acidic protein gene?

Glial fibrillary acidic protein. Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes and ependymal cells.

What is autoimmune fibrillary acidic protein ( GFAP ) Astrocytopathy?

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an inflammatory central nervous system (CNS) disorder. It may affect any anatomic region, rostrocaudally, from optic nerve to spinal cord, though meningoencephalitis is predominant.

How is GFAP used as a marker of neurologic damage?

GFAP levels are already used as a marker of neurologic damage in adults who suffer strokes and traumatic brain injuries. Glial fibrillary acidic protein has been shown to interact with MEN1 and PSEN1.

Can a glial scar be caused by GFAP?

The destruction of astrocytes can lead to the development of a glial scar . There are multiple disorders associated with improper GFAP regulation and glial scarring is a consequence of several neurodegenerative conditions.