Does excess vitamin D cause bone resorption?

2020-09-14 by No Comments

Does excess vitamin D cause bone resorption?

Previous studies have shown that high doses of vitamin D did result in increased resorption of bone unless calcium was also supplemented. The active form of vitamin D called calcitriol increases the production of osteoclasts which enhance bone resorption.

How does vitamin D stimulate bone resorption?

Active vitamin D compounds stimulate osteoclast formation in a co-culture of osteoblastic cells and hematopoietic cells. Osteoblastic cells express RANKL in response to 1α,25(OH)2D3. Therefore, 1α,25(OH)2D3 has been believed to stimulate osteoclastic bone resorption.

Does vitamin D cause bone resorption or deposition?

Vitamin D is generally associated not only with improved bone mineralization but also with increased bone resorption, and thus may seem to represent ‘good’ and ‘bad’ effects on bone.

Does vitamin D promote bone resorption?

Vitamin D-Regulated Bone Resorption In addition to its role in promoting bone formation, 1,25 (OH)2D promotes bone resorption by increasing the number and activity of osteoclasts [69].

Is it better to take vitamin D daily or weekly?

Daily vitamin D was more effective than weekly, and monthly administration was the least effective.

What triggers bone resorption?

Bone resorption is highly stimulated or inhibited by signals from other parts of the body, depending on the demand for calcium. Calcium-sensing membrane receptors in the parathyroid gland monitor calcium levels in the extracellular fluid.

Can vitamin D improve bone density?

Vitamin D status is related to bone mineral density and bone turnover. Vitamin D supplementation may decrease bone turnover and increase bone mineral density.

Can vitamin D cause bone problems?

Vitamin D deficiency causes osteomalacia in adults and rickets (i.e., soft bones, which may bow or fracture) in children. Osteomalacia possibly contributes to osteoporosis.

Is it good to take vitamin D3 everyday?

Most experts recommend that you shouldn’t take more than 4,000 IU of vitamin D a day. When your serum D3 is very low (less than 12 nanograms per milliliter), some may recommend a short course of once-weekly 50,000 IU of vitamin D2 or D3, followed by a usual dose of 600 to 800 IU daily.

How is vitamin D related to bone resorption?

Anti-resorptive effects in vivo are mediated by VDR in osteoblastic cells. Active forms of vitamin D enhance osteoclastogenesis in vitro and in vivo through the vitamin D receptor (VDR) in osteoblast-lineage cells consisting of osteoblasts and osteocytes.

How is vitamin D used to treat osteoporosis?

Nevertheless, vitamin D compounds have been used in Japan for treating osteoporosis to increase bone mineral density (BMD). Of note, the increase in BMD by long-term treatment with pharmacological (=near-physiological) doses of vitamin D compounds was caused by the suppression of bone resorption.

What causes bone loss at the mandibular condyle?

Bone loss at the mandibular condyle has been described as a result of orthognathic surgery, systemic and local arthritides, post-traumatic remodeling, and/or hormonal imbalance . Osseous condylar resorption that occurs without obvious cause is termed idiopathic condylar resorption (ICR).

How does vitamin D increase osteoclastogenesis in the body?

Active forms of vitamin D enhance osteoclastogenesis in vitro and in vivo through the vitamin D receptor (VDR) in osteoblast-lineage cells consisting of osteoblasts and osteocytes. This pro-resorptive activity was evident basically with higher concentrations of active vitamin D than those expected in physiological conditions.