What is apixaban and what are the side effects?

Written by Cerner Multum. What is apixaban? Apixaban is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation.

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How many apixaban tablets should I take a day?

The recommended dose of Apixaban tablets for most patients is 5 mg taken orally twice daily. The recommended dose of Apixaban tablets is 2.5 mg twice daily in patients with at least two of the following characteristics: Prophylaxis of Deep Vein Thrombosis Following Hip or Knee Replacement Surgery

Which is the FDA approved antidote for apixaban?

Andexanet alfa is a Food and Drug Administration (FDA) approved antidote for apixaban in people with uncontrolled and life-threatening bleeding events. Following spinal anesthesia or puncture people who are being treated with anti-thrombotic agents are at higher risk for developing a hematoma, which can cause long-term or permanent paralysis.

How are apixaban tablets used to treat stroke?

Apixaban tablets are indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Apixaban tablets are indicated for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.

What was the objective of the apixaban study?

The objective of this study was to quantify the degree of INR elevation in hospitalized patients receiving apixaban. This was a single-center, retrospective, observational analysis of adult patients who received at least 1 dose of apixaban during their hospital admission and had at least 1 INR sample collected prior to and following administration.

Is there an increase in INR with apixaban?

Apixaban is associated with a notable increase in INR in hospitalized patients, although it is not clear the clinical impact of the increase.