What is sevelamer hydrochloride used to treat?

Sevelamer is used to control high blood levels of phosphorus in people with chronic kidney disease who are on dialysis (medical treatment to clean the blood when the kidneys are not working properly). Sevelamer is in a class of medications called phosphate binders.

What is the difference between sevelamer carbonate and HCL?

Whereas the metal-based binders might be absorbed, the sevelamer hydrochloride and sevelamer carbonate are not absorbed. The main difference between sevelamer carbonate and sevelamer hydrochloride is that the chloride in the sevelamer resin was replaced by bicarbonate. That’s the only difference.

What are side effects of sevelamer?

Headache, diarrhea, stomach upset, nausea, vomiting, cough, gas, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Does renvela increase calcium?

Renvela binds to (or holds on to) phosphorus in the foods you eat so your body doesn’t absorb as much. Then it carries the phosphorus through your digestive tract and out of your body. Renvela does not contain calcium or metal and is not absorbed, so it does not build up in your body.

Why is phosphorus bad for kidneys?

When you have chronic kidney disease (CKD), your kidneys cannot remove phosphorus very well. High phosphorus levels can cause damage to your body. Extra phosphorus causes body changes that pull calcium out of your bones, making them weak.

Does sevelamer increase calcium?

Dosages of study medication increased in both groups during the study. Mean daily sevelamer dosage increased from 3.3 ± 2.0 to 5.0 ± 2.7 g after 1 yr, and calcium increased from 3.8 ± 2.2 to 4.0 ± 2.5 g.

What happens if phosphorus is too high?

High phosphorus levels can cause damage to your body. Extra phosphorus causes body changes that pull calcium out of your bones, making them weak. High phosphorus and calcium levels also lead to dangerous calcium deposits in blood vessels, lungs, eyes, and heart.

Does sevelamer cause gas?

Overall adverse reactions among those treated with sevelamer hydrochloride occurring in > 5% of patients included: vomiting (22%), nausea (20%), diarrhea (19%), dyspepsia (16%), abdominal pain (9%), flatulence (8%) and constipation (8%).

What foods are high in phosphorus?

Phosphorus is found in high amounts in protein foods such as milk and milk products and meat and alternatives, such as beans, lentils and nuts. Grains, especially whole grains provide phosphorus. Phosporus is found in smaller amounts in vegetables and fruit.

When to use sevelamer hydrochloride in CKD patients?

INDICATIONS AND USAGE Sevelamer hydrochloride tablets are indicated for the control of serum phosphorus in patients with chronic kidney disease (CKD) on dialysis. The safety and efficacy of sevelamer hydrochloride tablets in CKD patients who are not on dialysis have not been studied.

What do you need to know about sevelamer?

What is sevelamer? Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus. Sevelamer is used to control phosphorus levels in people with chronic kidney disease who are on dialysis.

Can a pregnant woman take sevelamer hydrochloride tablets?

Sevelamer carbonate is not absorbed systemically by the mother following oral administration, and breastfeeding is not expected to result in exposure of the child to sevelamer carbonate. Sevelamer carbonate may decrease serum levels of fat soluble vitamins and folic acid in pregnant women [see Clinical Pharmacology (12.2) ].

What is the chemical structure of sevelamer hydrochloride?

Figure 1: Chemical Structure of Sevelamer Hydrochloride The primary amine groups shown in the structure are derived directly from poly(allylamine  hydrochloride). The crosslinking groups consist of two secondary amine groups derived from  poly(allylamine hydrochloride) and one molecule of epichlorohydrin.