What is mineralocorticoid aldosterone?

The mineralocorticoid aldosterone (Aldo) is a steroid hormone synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex [1].

What is aldosterone structure?

C21H28O5
Aldosterone/Formula

What structure does aldosterone target?

Classical aldosterone target tissues are kidney, colon, sweat and salivary glands.

Which one of the following is an example of mineralocorticoid?

Mineralocorticoids (aldosterone), glucocorticoids (cortisol, corticosterone), and sex steroids (androgens, estrogens, progesterone) are metabolized by the liver.

Can cortisol act like aldosterone?

In tissues in which the enzyme is not expressed, MRs are overwhelmingly occupied but not activated by cortisol, which normally thus acts as an MR antagonist; in tissue damage, however, cortisol mimics aldosterone and acts as an MR agonist.

What is the main function of aldosterone?

Aldosterone is a steroid hormone. Its main role is to regulate salt and water in the body, thus having an effect on blood pressure.

Why is aldosterone called a mineralocorticoid?

The name mineralocorticoid derives from early observations that these hormones were involved in the retention of sodium, a mineral. The primary endogenous mineralocorticoid is aldosterone, although a number of other endogenous hormones (including progesterone and deoxycorticosterone) have mineralocorticoid function.

What does mineralocorticoid mean?

Medical Definition of mineralocorticoid. : a corticosteroid (as aldosterone ) that affects chiefly the electrolyte and fluid balance in the body — compare glucocorticoid .

What is the antagonist of aldosterone?

Jump to navigation Jump to search. An antimineralocorticoid, MCRA, or an aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors . This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure.

What is antagonistic hormone to actions of aldosterone?

Aldosterone receptor antagonists (also called an antimineralocorticoid, MCRA, and sometimes MRA) are a class of drugs which block the effects of aldosterone. Aldosterone is the main mineralocorticoid hormone in the body and is produced in the adrenal cortex of the adrenal gland.

What is the mechanism of action of aldosterone?

Antimineralocorticoid mechanism of action. Aldosterone is a mineralocorticoid which is synthesized in the adrenal glands. When aldosterone is secreted from the adrenal glands, it binds to the mineralocorticoid receptor in the renal tubule cell and forms a complex.